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Try to cut down on nicotinealcohol and hot drinks containing caffeinesuch as tea and coffeeDress in layersso you can remove clothes as neededWear clothes made from natural fabricssuch as cotton.

Let your doctor or nurse know if you continue to feel sickor if you have indigestionThey can give you advice or prescribe drugs to help.

Men can read more about coping with hot flushes in our section on managing hormonal symptoms.

You should also tell them if you have any discomfort in the lower tummypelvissuch as pain or pressureThese can be early signs of womb canceralthough they are usually caused by other conditionsIf womb cancer is found earlytreatment can be very successful.

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tamoxifen is metabolized by cyp3a4 and cyp2d6, and to a smaller extent by cyp2c9 and cyp2c19, to other potent, active metabolites including endoxifen, which have up to 33 times more affinity for the estrogen receptor than tamoxifen.

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